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Polidocanol

CHEMBL6067961 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
582.8 g/mol
LogP
3.9
Phase
4

Polidocanol is a sclerosant agent and local anesthetic belonging to the fatty alcohol polyethylene oxide class that causes endothelial cell injury and subsequent fibrosis when injected into blood vessels or varicose veins. It is used for sclerotherapy of varicose veins, esophageal varices, and hemorrhoids, and has also been used topically as a mild local anesthetic for pruritis relief.

Khối lượng phân tử

582,8000 g/mol

LogP

3,90

TPSA

103,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Melanoma Gastroesophageal Reflux Disease Hypertension

Cơ chế tác dụng

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

SMILES

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

InChI

InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3

Molecular Formula

C30H62O10

HBD / HBA

1 / 10

Liên kết có thể quay

37

Nguyên tử nặng

40

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Câu hỏi thường gặp

Polidocanol is a sclerosant agent and local anesthetic belonging to the fatty alcohol polyethylene oxide class that causes endothelial cell injury and subsequent fibrosis when injected into blood vessels or varicose veins. It is used for sclerotherapy of varicose veins, esophageal varices, and hemorrhoids, and has also been used topically as a mild local anesthetic for pruritis relief.

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Yes, Polidocanol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6067961. Open-access bioactivity database.
  • PubChem — National Center for Biotechnology Information (NCBI). CID 656641. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

Tuyên bố miễn trách y tế

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.