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Rilmenidine

CHEMBL289480 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
180.2 g/mol
LogP
1.2
Phase
4

Rilmenidine is a selective imidazoline I1 receptor agonist and alpha-2 adrenergic agonist that reduces sympathetic outflow from the central nervous system by acting on imidazoline receptors in the rostral ventrolateral medulla and nucleus tractus solitarius, thereby decreasing peripheral vascular resistance and heart rate. It is used for the treatment of hypertension with a more favorable side effect profile than older central antihypertensives.

Khối lượng phân tử

180,2500 g/mol

LogP

1,20

TPSA

33,60 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Chronic Kidney Disease Hypertension

Cơ chế tác dụng

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C1COC(NC(C2CC2)C2CC2)=N1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H16N2O

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Rilmenidine is a selective imidazoline I1 receptor agonist and alpha-2 adrenergic agonist that reduces sympathetic outflow from the central nervous system by acting on imidazoline receptors in the rostral ventrolateral medulla and nucleus tractus solitarius, thereby decreasing peripheral vascular resistance and heart rate. It is used for the treatment of hypertension with a more favorable side effect profile than older central antihypertensives.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Rilmenidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL289480.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 68712.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.