Rose Bengal Free Acid
Rose bengal free acid is a halogenated fluorescein dye with photosensitizing properties, used diagnostically to stain devitalized cells in ophthalmology and experimentally as a photodynamic therapy agent. It generates reactive oxygen species upon light activation, inducing cell death in targeted tissues. The compound is under investigation for intralesional treatment of solid tumors.
Khối lượng phân tử
973,7000 g/mol
LogP
7,60
TPSA
83,80 Ų
Lipinski RO5
Không đạt
Cơ chế tác dụng
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
O=C(O)c1c(Cl)c(Cl)c(Cl)c(Cl)c1-c1c2cc(I)c(=O)c(I)c-2oc2c(I)c(O)c(I)cc12
InChI
InChI=1S/C20H4Cl4I4O5/c21-10-8(9(20(31)32)11(22)13(24)12(10)23)7-3-1-5(25)16(29)14(27)18(3)33-19-4(7)2-6(26)17(30)15(19)28/h1-2,29H,(H,31,32)
Molecular Formula
C20H4Cl4I4O5
HBD / HBA
2 / 5
Liên kết có thể quay
2
Nguyên tử nặng
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Rose bengal free acid is a halogenated fluorescein dye with photosensitizing properties, used diagnostically to stain devitalized cells in ophthalmology and experimentally as a photodynamic therapy agent. It generates reactive oxygen species upon light activation, inducing cell death in targeted tissues. The compound is under investigation for intralesional treatment of solid tumors.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Rose Bengal Free Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1208422. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25474. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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