Rotigotine
Rotigotine is a non-ergoline dopamine receptor agonist delivered transdermally, used primarily for the treatment of Parkinson's disease and restless legs syndrome, with investigational applications in Alzheimer's disease and epilepsy. It acts as an agonist at D1, D2, and D3 dopamine receptors, as well as alpha-adrenergic and serotonin receptors, restoring dopaminergic tone in the striatum. Continuous transdermal delivery provides stable plasma levels, reducing motor fluctuations.
Khối lượng phân tử
315,5000 g/mol
LogP
4,90
TPSA
51,70 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
InChI
InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
Molecular Formula
C19H25NOS
HBD / HBA
1 / 3
Liên kết có thể quay
6
Nguyên tử nặng
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Rotigotine is a non-ergoline dopamine receptor agonist delivered transdermally, used primarily for the treatment of Parkinson's disease and restless legs syndrome, with investigational applications in Alzheimer's disease and epilepsy. It acts as an agonist at D1, D2, and D3 dopamine receptors, as well as alpha-adrenergic and serotonin receptors, restoring dopaminergic tone in the striatum. Continuous transdermal delivery provides stable plasma levels, reducing motor fluctuations.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Rotigotine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1303. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 59227. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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