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Sincalide

CHEMBL1121 Phase 4 Đã phê duyệt Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1143.3 g/mol
LogP
-2.6
Phase
4

Sincalide is a synthetic C-terminal octapeptide fragment of cholecystokinin (CCK) used diagnostically to stimulate gallbladder contraction for cholescintigraphy and to assess pancreatic exocrine function. By binding to CCK receptors in the gallbladder smooth muscle and pancreatic acinar cells, it mimics endogenous CCK-induced contraction and enzyme secretion. It enables dynamic assessment of gallbladder ejection fraction and pancreatic secretory capacity in nuclear medicine and GI function tests.

Khối lượng phân tử

1143,3000 g/mol

LogP

-2,60

TPSA

486,00 Ų

Lipinski RO5

Không đạt

Cơ chế tác dụng

Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

                

                

                
                

                    
InChI

                    
InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C49H62N10O16S3

                    

                    
                    

                        
HBD / HBA

                        
13 / 19

                    

                    
                    

                        
Liên kết có thể quay

                        
33

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
78

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Sincalide is a synthetic C-terminal octapeptide fragment of cholecystokinin (CCK) used diagnostically to stimulate gallbladder contraction for cholescintigraphy and to assess pancreatic exocrine function. By binding to CCK receptors in the gallbladder smooth muscle and pancreatic acinar cells, it mimics endogenous CCK-induced contraction and enzyme secretion. It enables dynamic assessment of gallbladder ejection fraction and pancreatic secretory capacity in nuclear medicine and GI function tests.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sincalide is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1121.
                Open-access bioactivity database.
            
        
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                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9833444.
                Chemical information database.
            
        
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Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.