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Sofosbuvir

CHEMBL1259059 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
529.5 g/mol
LogP
1.0
Phase
4

A cornerstone of modern hepatitis C treatment, this once-daily antiviral blocks a key enzyme the hepatitis C virus needs to copy itself. When combined with other antivirals, it achieves cure rates above 95% in most patients after just 8 to 12 weeks of treatment, with minimal side effects.

Khối lượng phân tử

529,5000 g/mol

LogP

1,00

TPSA

153,00 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Lymphoma Hypertension HIV/AIDS Hepatitis C Heart Failure Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H29FN3O9P

                    

                    
                    

                        
HBD / HBA

                        
3 / 11

                    

                    
                    

                        
Liên kết có thể quay

                        
11

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
36

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A cornerstone of modern hepatitis C treatment, this once-daily antiviral blocks a key enzyme the hepatitis C virus needs to copy itself. When combined with other antivirals, it achieves cure rates above 95% in most patients after just 8 to 12 weeks of treatment, with minimal side effects.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Sofosbuvir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1259059.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 45375808.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.