Teneligliptin
Teneligliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the degradation of incretin hormones GLP-1 and GIP, thereby enhancing glucose-dependent insulin secretion, suppressing glucagon release, and improving glycemic control in type 2 diabetes. Its unique thiazolidine-based structure provides prolonged DPP-4 inhibition and is approved in Japan, South Korea, and India for type 2 diabetes management. It may have additional cardiovascular benefits through reduction of myocardial remodeling, making it of interest in heart failure research.
Khối lượng phân tử
426,6000 g/mol
LogP
2,40
TPSA
81,90 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1
InChI
InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1
Molecular Formula
C22H30N6OS
HBD / HBA
1 / 6
Liên kết có thể quay
4
Nguyên tử nặng
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Teneligliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the degradation of incretin hormones GLP-1 and GIP, thereby enhancing glucose-dependent insulin secretion, suppressing glucagon release, and improving glycemic control in type 2 diabetes. Its unique thiazolidine-based structure provides prolonged DPP-4 inhibition and is approved in Japan, South Korea, and India for type 2 diabetes management. It may have additional cardiovascular benefits through reduction of myocardial remodeling, making it of interest in heart failure research.
Yes, Teneligliptin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2147777. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11949652. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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