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Tezepelumab

CHEMBL3707229 Phase 4 Đã phê duyệt Antibody
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin (TSLP), an epithelial cytokine at the top of the inflammatory cascade that drives IgE production, eosinophil activation, and Th2 inflammation in asthma and atopic dermatitis. It is approved as add-on maintenance therapy for severe asthma regardless of eosinophil phenotype, making it unique among biologics in treating non-eosinophilic asthma. By blocking upstream TSLP, it broadly suppresses multiple allergic and non-allergic inflammatory pathways.

Lĩnh vực điều trị

Asthma Chronic Obstructive Pulmonary Disease Atopic Dermatitis

Cơ chế tác dụng

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Câu hỏi thường gặp

Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin (TSLP), an epithelial cytokine at the top of the inflammatory cascade that drives IgE production, eosinophil activation, and Th2 inflammation in asthma and atopic dermatitis. It is approved as add-on maintenance therapy for severe asthma regardless of eosinophil phenotype, making it unique among biologics in treating non-eosinophilic asthma. By blocking upstream TSLP, it broadly suppresses multiple allergic and non-allergic inflammatory pathways.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Tezepelumab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3707229. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

Tuyên bố miễn trách y tế

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.