Thenalidine
Thenalidine is a first-generation antihistamine with anticholinergic and anti-serotonin properties that blocks H1 histamine receptors, used historically for allergic conditions including urticaria and pruritus. It was withdrawn from markets due to serious hematological adverse effects including agranulocytosis and neutropenia. Its sedative properties were typical of first-generation antihistamines due to CNS histamine H1 receptor blockade.
Khối lượng phân tử
286,4000 g/mol
LogP
3,80
TPSA
34,70 Ų
Lipinski RO5
Đạt
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CN1CCC(N(Cc2cccs2)c2ccccc2)CC1
InChI
InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3
Molecular Formula
C17H22N2S
HBD / HBA
- / 3
Liên kết có thể quay
4
Nguyên tử nặng
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Thenalidine is a first-generation antihistamine with anticholinergic and anti-serotonin properties that blocks H1 histamine receptors, used historically for allergic conditions including urticaria and pruritus. It was withdrawn from markets due to serious hematological adverse effects including agranulocytosis and neutropenia. Its sedative properties were typical of first-generation antihistamines due to CNS histamine H1 receptor blockade.
Yes, Thenalidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105458. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 27901. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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