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Thiopental

CHEMBL441 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
242.3 g/mol
LogP
2.9
Phase
4

This fast-acting barbiturate has been used as an intravenous anesthetic to induce unconsciousness before surgery and in emergency settings such as controlling severe seizures or reducing brain swelling. It works by enhancing the effects of GABA, a calming neurotransmitter in the brain. Its use has largely been replaced by newer anesthetic agents in many countries.

Khối lượng phân tử

242,3400 g/mol

LogP

2,90

TPSA

90,30 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pancreatic Cancer Glaucoma Age-Related Macular Degeneration Pain Management Generalized Anxiety Disorder Gastroesophageal Reflux Disease Obesity Hypertension Breast Cancer Chronic Pain

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCC(C)C1(CC)C(=O)NC(=S)NC1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C11H18N2O2S

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This fast-acting barbiturate has been used as an intravenous anesthetic to induce unconsciousness before surgery and in emergency settings such as controlling severe seizures or reducing brain swelling. It works by enhancing the effects of GABA, a calming neurotransmitter in the brain. Its use has largely been replaced by newer anesthetic agents in many countries.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Thiopental is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL441.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3000715.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.