Tolazamide
Tolazamide is a first-generation sulfonylurea that stimulates insulin secretion from pancreatic beta cells by binding to and blocking ATP-sensitive potassium channels (KATP), causing membrane depolarization, calcium influx, and insulin granule exocytosis. It is used as an oral antidiabetic agent for type 2 diabetes in patients where diet and exercise are insufficient, and has also been used in cardiovascular risk stratification studies. Its mechanism depends on functional beta cells and is ineffective in type 1 diabetes.
Khối lượng phân tử
311,4000 g/mol
LogP
1,50
TPSA
86,90 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Cc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1
InChI
InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
Molecular Formula
C14H21N3O3S
HBD / HBA
2 / 4
Liên kết có thể quay
3
Nguyên tử nặng
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Tolazamide is a first-generation sulfonylurea that stimulates insulin secretion from pancreatic beta cells by binding to and blocking ATP-sensitive potassium channels (KATP), causing membrane depolarization, calcium influx, and insulin granule exocytosis. It is used as an oral antidiabetic agent for type 2 diabetes in patients where diet and exercise are insufficient, and has also been used in cardiovascular risk stratification studies. Its mechanism depends on functional beta cells and is ineffective in type 1 diabetes.
Yes, Tolazamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL817. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5503. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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