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Tovorafenib

CHEMBL3348923 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
506.3 g/mol
LogP
3.0
Phase
4

Tovorafenib is an oral, brain-penetrant, RAF kinase inhibitor that selectively inhibits BRAF monomers and dimers (including BRAF V600E mutations and certain non-V600E alterations) by functioning as a type II RAF inhibitor, blocking MAPK pathway-driven tumor cell proliferation. It is approved for pediatric patients with relapsed or refractory BRAF-altered pediatric low-grade glioma, and is under investigation for adult BRAF-altered cancers including colorectal and bladder cancers. Its once-weekly dosing and CNS penetration distinguish it from other RAF inhibitors.

Khối lượng phân tử

506,3000 g/mol

LogP

3,00

TPSA

164,00 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

Melanoma Pancreatic Cancer Bladder Cancer Thyroid Cancer Colorectal Cancer Leukemia

Cơ chế tác dụng

Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1

                

                

                
                

                    
InChI

                    
InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H12Cl2F3N7O2S

                    

                    
                    

                        
HBD / HBA

                        
3 / 11

                    

                    
                    

                        
Liên kết có thể quay

                        
5

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Tovorafenib is an oral, brain-penetrant, RAF kinase inhibitor that selectively inhibits BRAF monomers and dimers (including BRAF V600E mutations and certain non-V600E alterations) by functioning as a type II RAF inhibitor, blocking MAPK pathway-driven tumor cell proliferation. It is approved for pediatric patients with relapsed or refractory BRAF-altered pediatric low-grade glioma, and is under investigation for adult BRAF-altered cancers including colorectal and bladder cancers. Its once-weekly dosing and CNS penetration distinguish it from other RAF inhibitors.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tovorafenib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3348923.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 25161177.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.