Trimeprazine Tartrate
Trimeprazine tartrate is a phenothiazine derivative with potent antihistamine and sedative properties, acting as an H1 receptor antagonist with additional anticholinergic and antidopaminergic effects. It is used to relieve pruritus (itching) associated with allergic conditions and as a preoperative sedative, particularly in pediatric patients. The tartrate salt form enhances solubility for pharmaceutical formulation.
Khối lượng phân tử
747,0000 g/mol
TPSA
179,00 Ų
Cơ chế tác dụng
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CC(CN(C)C)CN1c2ccccc2Sc2ccccc21.CC(CN(C)C)CN1c2ccccc2Sc2ccccc21.O=C(O)C(O)C(O)C(=O)O
InChI
InChI=1S/2C18H22N2S.C4H6O6/c2*1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h2*4-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)
Molecular Formula
C40H50N4O6S2
HBD / HBA
4 / 12
Liên kết có thể quay
11
Nguyên tử nặng
52
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Trimeprazine tartrate is a phenothiazine derivative with potent antihistamine and sedative properties, acting as an H1 receptor antagonist with additional anticholinergic and antidopaminergic effects. It is used to relieve pruritus (itching) associated with allergic conditions and as a preoperative sedative, particularly in pediatric patients. The tartrate salt form enhances solubility for pharmaceutical formulation.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Trimeprazine Tartrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989885. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 441236. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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