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Trimetrexate

CHEMBL119 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
369.4 g/mol
LogP
2.5
Phase
4

Trimetrexate is a lipophilic antifolate that inhibits dihydrofolate reductase (DHFR), blocking tetrahydrofolate synthesis required for DNA replication, thereby exerting cytotoxic effects on rapidly dividing cells. It was used as an alternative treatment for Pneumocystis jirovecii pneumonia in immunocompromised patients and investigated as an antineoplastic agent in colorectal cancer and leukemia. It requires leucovorin rescue to protect normal host cells.

Khối lượng phân tử

369,4000 g/mol

LogP

2,50

TPSA

118,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pancreatic Cancer Lymphoma Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H23N5O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 8

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Trimetrexate is a lipophilic antifolate that inhibits dihydrofolate reductase (DHFR), blocking tetrahydrofolate synthesis required for DNA replication, thereby exerting cytotoxic effects on rapidly dividing cells. It was used as an alternative treatment for Pneumocystis jirovecii pneumonia in immunocompromised patients and investigated as an antineoplastic agent in colorectal cancer and leukemia. It requires leucovorin rescue to protect normal host cells.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Trimetrexate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL119.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5583.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.