Tripelennamine
Tripelennamine is a first-generation H1 antihistamine that competitively blocks histamine at H1 receptors, reducing allergic symptoms such as itching, urticaria, rhinorrhea, and conjunctivitis. It has significant sedative and anticholinergic properties due to central nervous system penetration. It was used for allergic conditions and as a component in some illicit drug preparations due to its CNS effects.
Khối lượng phân tử
255,3600 g/mol
LogP
3,30
TPSA
19,40 Ų
Lipinski RO5
Đạt
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CN(C)CCN(Cc1ccccc1)c1ccccn1
InChI
InChI=1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3
Molecular Formula
C16H21N3
HBD / HBA
- / 3
Liên kết có thể quay
6
Nguyên tử nặng
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Tripelennamine is a first-generation H1 antihistamine that competitively blocks histamine at H1 receptors, reducing allergic symptoms such as itching, urticaria, rhinorrhea, and conjunctivitis. It has significant sedative and anticholinergic properties due to central nervous system penetration. It was used for allergic conditions and as a component in some illicit drug preparations due to its CNS effects.
Yes, Tripelennamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1241. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5587. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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