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Trospium

CHEMBL1888176 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
392.5 g/mol
LogP
4.4
Phase
4

Trospium is a quaternary ammonium antimuscarinic agent that blocks muscarinic M3 receptors in the detrusor muscle of the bladder, reducing involuntary contractions and increasing bladder capacity. It is used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. Its quaternary structure limits CNS penetration, reducing cognitive side effects compared to tertiary antimuscarinics.

Khối lượng phân tử

392,5000 g/mol

LogP

4,40

TPSA

46,50 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Chronic Obstructive Pulmonary Disease Alzheimer's Disease Schizophrenia Bipolar Disorder Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(O[C@H]1C[C@H]2CC[C@@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H30NO3+

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Liên kết có thể quay

                        
5

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Trospium is a quaternary ammonium antimuscarinic agent that blocks muscarinic M3 receptors in the detrusor muscle of the bladder, reducing involuntary contractions and increasing bladder capacity. It is used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. Its quaternary structure limits CNS penetration, reducing cognitive side effects compared to tertiary antimuscarinics.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Trospium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1888176.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5284632.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.