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Uridine Triacetate

CHEMBL2107381 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
370.3 g/mol
LogP
-0.5
Phase
4

Uridine triacetate is a prodrug that is cleaved in vivo to release uridine, which competitively inhibits the incorporation of fluorouracil (5-FU) metabolites into RNA and DNA, thereby rescuing normal cells from 5-FU toxicity. It is used as an antidote for 5-FU overdose or early-onset severe toxicity from 5-FU or capecitabine chemotherapy, and is also approved for hereditary orotic aciduria, a rare enzyme deficiency causing abnormal pyrimidine metabolism. Its mechanism of flooding the uridine pool reduces the relative incorporation of toxic 5-FU metabolites.

Khối lượng phân tử

370,3100 g/mol

LogP

-0,50

TPSA

138,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pancreatic Cancer

Cơ chế tác dụng

Counteracts the effects of a specific toxin or drug overdose through competitive antagonism, enhanced elimination, or direct chemical neutralization.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Counteracts the effects of a specific toxin or drug overdose through competitive antagonism, enhanced elimination, or direct chemical neutralization.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O

                

                

                
                

                    
InChI

                    
InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H18N2O9

                    

                    
                    

                        
HBD / HBA

                        
1 / 9

                    

                    
                    

                        
Liên kết có thể quay

                        
8

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Uridine triacetate is a prodrug that is cleaved in vivo to release uridine, which competitively inhibits the incorporation of fluorouracil (5-FU) metabolites into RNA and DNA, thereby rescuing normal cells from 5-FU toxicity. It is used as an antidote for 5-FU overdose or early-onset severe toxicity from 5-FU or capecitabine chemotherapy, and is also approved for hereditary orotic aciduria, a rare enzyme deficiency causing abnormal pyrimidine metabolism. Its mechanism of flooding the uridine pool reduces the relative incorporation of toxic …

                        

                    

                    

                    

                    
                    

                        
                        

                            
Counteracts the effects of a specific toxin or drug overdose through competitive antagonism, enhanced elimination, or direct chemical neutralization.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Uridine Triacetate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2107381.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 20058.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.