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Votumumab

CHEMBL2108157 Phase 4 Đã phê duyệt Antibody
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

Votumumab is a human monoclonal antibody that targets cytokeratin 8 (CK8), an intracellular intermediate filament protein that becomes exposed on the surface of apoptotic tumor cells, enabling tumor-selective antibody binding. It was developed as an immunoconjugate or tumor-targeted antibody for various carcinomas expressing CK8. Its unique target on apoptotic tumor surfaces was investigated for both diagnostic imaging and therapeutic applications.

Cơ chế tác dụng

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Câu hỏi thường gặp

Votumumab is a human monoclonal antibody that targets cytokeratin 8 (CK8), an intracellular intermediate filament protein that becomes exposed on the surface of apoptotic tumor cells, enabling tumor-selective antibody binding. It was developed as an immunoconjugate or tumor-targeted antibody for various carcinomas expressing CK8. Its unique target on apoptotic tumor surfaces was investigated for both diagnostic imaging and therapeutic applications.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Votumumab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2108157. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

Tuyên bố miễn trách y tế

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.