Major
Probable
Mô tả
Co-administration of alprazolam and quetiapine produces additive CNS depression with risk of profound sedation and respiratory compromise.
Cơ chế
Both agents have CNS depressant properties via distinct receptors: alprazolam via GABA-A and quetiapine via H1/D2/alpha-1 receptor blockade; additive inhibitory effects on CNS excitability occur.
Ý nghĩa lâm sàng
The combination is associated with excess mortality in pharmacoepidemiological data, particularly in elderly patients with psychiatric illness.
Xử trí
Use with caution; monitor closely for excessive sedation and respiratory depression; avoid in patients with sleep apnea.