Minor
Suspected
Mô tả
Diphenhydramine may modestly reduce aspirin absorption and slightly impair its antiplatelet efficacy through delayed gastric emptying; the clinical significance is generally low.
Cơ chế
Diphenhydramine's anticholinergic properties slow gastric motility, potentially delaying aspirin absorption and reducing its early platelet-inhibitory effect.
Ý nghĩa lâm sàng
The effect on platelet inhibition is small and transient; relevant primarily if rapid antiplatelet action is needed (e.g., acute chest pain).
Xử trí
No routine dose adjustment required; if rapid aspirin loading is critical, use a non-enteric-coated chewed aspirin and avoid anticholinergic premedication.