Major
Established
Mô tả
Cyclosporine raises simvastatin exposure by 6- to 10-fold through inhibition of CYP3A4, OATP1B1, and P-gp, creating an extremely high risk of rhabdomyolysis.
Cơ chế
Simvastatin acid depends on CYP3A4 for metabolism, OATP1B1 for hepatocyte uptake, and P-gp for efflux; cyclosporine's broad transporter/enzyme inhibition blocks all clearance pathways.
Ý nghĩa lâm sàng
This combination is contraindicated; multiple cases of severe and fatal rhabdomyolysis have been reported in transplant recipients.
Xử trí
Contraindicated. Do not use simvastatin in patients taking cyclosporine. Use pravastatin or fluvastatin at low doses instead.