Enalapril vs Hydrochlorothiazide

## Enalapril vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Enalapril** and **Hydrochlorothiazide**.

## Mechanism of Action

**Enalapril**: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Enalapril — 11 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Enalapril — C20H28N2O5; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Enalapril — 376.4470 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Enalapril — Small molecule; Hydrochlorothiazide — Small molecule.