Fentanyl vs Tramadol

## Fentanyl vs Tramadol: Overview

This comparison examines the pharmacological differences between **Fentanyl** and **Tramadol**.

## Mechanism of Action

**Fentanyl**: Highly potent synthetic mu-opioid receptor agonist approximately 100 times more potent than morphine.

**Tramadol**: Mu-opioid receptor agonist and serotonin-norepinephrine reuptake inhibitor.

## Pharmacokinetics

**Half-life**: Fentanyl — 2-4 hours; Tramadol — 5-7 hours.

## Chemical Properties

**Molecular Formula**: Fentanyl — C22H28N2O; Tramadol — C16H25NO2.

**Molecular Weight**: Fentanyl — 336.4700 g/mol; Tramadol — 263.3750 g/mol.

**Type**: Fentanyl — Small molecule; Tramadol — Small molecule.