Alectinib

CHEMBL1738797 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

482.6 g/mol

LogP

5.2

Phase

4

A targeted therapy that selectively blocks an abnormal protein called ALK that drives the growth of certain cancers, particularly non-small cell lung cancer with ALK gene rearrangements. By precisely inhibiting this signaling pathway, alectinib helps stop tumor growth and has good penetration into the brain, making it effective against cancer that has spread there.

分子量

482.6000 g/mol

LogP

5.20

TPSA

72.40 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Melanoma Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O

InChI

InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3

Molecular Formula

C30H34N4O2

HBD / HBA

1 / 5

可旋转键数

3

重原子数

36

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A targeted therapy that selectively blocks an abnormal protein called ALK that drives the growth of certain cancers, particularly non-small cell lung cancer with ALK gene rearrangements. By precisely inhibiting this signaling pathway, alectinib helps stop tumor growth and has good penetration into the brain, making it effective against cancer that has spread there.

Yes, Alectinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1738797. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 49806720. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C30H34N4O2
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.