Aminohippuric Acid

CHEMBL463 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

194.2 g/mol

LogP

-0.9

Phase

4

Measurement rather than treatment is the purpose of para-aminohippuric acid, a diagnostic agent used to quantify renal plasma flow and tubular secretory capacity. The kidney extracts it from plasma almost completely in a single pass, combining glomerular filtration with active tubular secretion, so its clearance approximates renal plasma flow more closely than that of any endogenous marker. The same near-complete extraction makes the substance useful for probing the secretory capacity of the proximal tubule when that function is in question. It is a small molecule with the formula C9H10N2O3 and a molecular weight close to 194.2 g/mol. The agent is approved and has completed the final phase of clinical development.

Para-aminohippuric acid (PAH) is used as a diagnostic tool to assess kidney function, specifically renal plasma flow and tubular secretory capacity. The kidney almost completely removes it from the blood in a single pass, making the clearance rate a reliable measure of renal blood flow.

分子量

194.1900 g/mol

LogP

-0.90

TPSA

92.40 Å²

Lipinski 五规则

符合

治疗领域

Nephrology

作用机制

Para-aminohippurate is filtered at the glomerulus and then almost completely secreted by the organic anion transporters of the proximal tubule, so a single pass through the kidney clears it from plasma. Its clearance therefore approximates effective renal plasma flow, and at high plasma concentrations, where the secretory transporters saturate, the transport maximum measures proximal tubular secretory capacity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Para-aminohippurate is filtered at the glomerulus and then almost completely secreted by the organic anion transporters of the proximal tubule, so a single pass through the kidney clears it from …

二维结构

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SMILES

Nc1ccc(C(=O)NCC(=O)O)cc1

InChI

InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)

Molecular Formula

C9H10N2O3

HBD / HBA

3 / 4

可旋转键数

3

重原子数

14

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Para-aminohippuric acid (PAH) is used as a diagnostic tool to assess kidney function, specifically renal plasma flow and tubular secretory capacity. The kidney almost completely removes it from the blood in a single pass, making the clearance rate a reliable measure of renal blood flow.

Para-aminohippurate is filtered at the glomerulus and then almost completely secreted by the organic anion transporters of the proximal tubule, so a single pass through the kidney clears it from plasma. Its clearance therefore approximates effective renal plasma flow, and at high plasma concentrations, where the secretory transporters saturate, the transport maximum measures proximal tubular secretory capacity.

Yes, Aminohippuric Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL463. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 2148. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.

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结构

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分子式: C9H10N2O3

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.