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Bedaquiline

CHEMBL376488 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
555.5 g/mol
LogP
7.2
Phase
4

A diarylquinolinyl antibiotic that specifically inhibits the ATP synthase of Mycobacterium tuberculosis, blocking the bacterium's energy production. It is a critical component of regimens for multidrug-resistant tuberculosis.

分子量

555.5000 g/mol

LogP

7.20

TPSA

45.60 Ų

Lipinski 五规则

不符合

治疗领域

Type 2 Diabetes HIV/AIDS Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1nc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1cccc2ccccc12

                

                

                
                

                    
InChI

                    
InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C32H31BrN2O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
可旋转键数

                        
8

                    

                    
                    
                    

                        
重原子数

                        
37

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A diarylquinolinyl antibiotic that specifically inhibits the ATP synthase of Mycobacterium tuberculosis, blocking the bacterium's energy production. It is a critical component of regimens for multidrug-resistant tuberculosis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Bedaquiline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL376488.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5388906.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.