Butabarbital
An intermediate-acting barbiturate used historically as a sedative and hypnotic for insomnia and anxiety. It acts by enhancing GABA-A receptor activity to produce sedation and sleep. It has largely been replaced by benzodiazepines and other hypnotics due to a narrower safety margin and higher abuse potential.
分子量
212.2500 g/mol
LogP
1.60
TPSA
75.30 Ų
Lipinski 五规则
符合
作用机制
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
二维结构
Cite this structure
Embed this structure
SMILES
CCC(C)C1(CC)C(=O)NC(=O)NC1=O
InChI
InChI=1S/C10H16N2O3/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)
Molecular Formula
C10H16N2O3
HBD / HBA
2 / 3
可旋转键数
3
重原子数
15
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
An intermediate-acting barbiturate used historically as a sedative and hypnotic for insomnia and anxiety. It acts by enhancing GABA-A receptor activity to produce sedation and sleep. It has largely been replaced by benzodiazepines and other hypnotics due to a narrower safety margin and higher abuse potential.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Butabarbital is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL449. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2479. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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