Butabarbital
An intermediate-acting barbiturate used historically as a sedative and hypnotic for insomnia and anxiety. It acts by enhancing GABA-A receptor activity to produce sedation and sleep. It has largely been replaced by benzodiazepines and other hypnotics due to a narrower safety margin and higher abuse potential.
Molecular Weight
212.2500 g/mol
LogP
1.60
TPSA
75.30 Ų
Lipinski RO5
Pass
Mechanism of Action
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
2D Structure
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SMILES
CCC(C)C1(CC)C(=O)NC(=O)NC1=O
InChI
InChI=1S/C10H16N2O3/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)
Molecular Formula
C10H16N2O3
HBD / HBA
2 / 3
Rotatable Bonds
3
Heavy Atoms
15
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
An intermediate-acting barbiturate used historically as a sedative and hypnotic for insomnia and anxiety. It acts by enhancing GABA-A receptor activity to produce sedation and sleep. It has largely been replaced by benzodiazepines and other hypnotics due to a narrower safety margin and higher abuse potential.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Butabarbital is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL449. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2479. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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