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Cabotegravir

CHEMBL2403238 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
405.4 g/mol
LogP
2.1
Phase
4

An HIV integrase strand transfer inhibitor available in both oral and long-acting injectable forms. The injectable formulation represents a major advance, allowing HIV treatment or pre-exposure prophylaxis with once-monthly or every-two-month injections rather than daily pills. It is co-formulated or co-administered with rilpivirine for complete antiretroviral therapy.

分子量

405.4000 g/mol

LogP

2.10

TPSA

99.20 Ų

Lipinski 五规则

符合

治疗领域

HIV/AIDS Tuberculosis

作用机制

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12

                

                

                
                

                    
InChI

                    
InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H17F2N3O5

                    

                    
                    

                        
HBD / HBA

                        
2 / 8

                    

                    
                    

                        
可旋转键数

                        
3

                    

                    
                    
                    

                        
重原子数

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
An HIV integrase strand transfer inhibitor available in both oral and long-acting injectable forms. The injectable formulation represents a major advance, allowing HIV treatment or pre-exposure prophylaxis with once-monthly or every-two-month injections rather than daily pills. It is co-formulated or co-administered with rilpivirine for complete antiretroviral therapy.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cabotegravir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2403238.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 54713659.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.