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Chlorhexidine

CHEMBL790 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
505.4 g/mol
LogP
0.1
Phase
4

A broad-spectrum antiseptic agent that disrupts microbial cell membranes, effective against bacteria, fungi, and some viruses, used extensively for skin and wound disinfection, hand sanitization, and oral hygiene. It binds to skin and mucous membranes for prolonged residual antimicrobial activity. It is a cornerstone of infection control protocols in healthcare settings.

分子量

505.4000 g/mol

LogP

0.10

TPSA

178.00 Ų

Lipinski 五规则

不符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Benign Prostatic Hyperplasia Glaucoma Cardiovascular Disease Age-Related Macular Degeneration Pain Management Ophthalmology Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Schizophrenia Generalized Anxiety Disorder Infectious Disease Nephrology Gastroesophageal Reflux Disease Inflammatory Bowel Disease Chronic Kidney Disease Stroke Deep Vein Thrombosis / Pulmonary Embolism Obesity Lymphoma Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Atopic Dermatitis Chronic Pain HIV/AIDS Hepatitis C Tuberculosis Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

作用机制

Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H30Cl2N10

                    

                    
                    

                        
HBD / HBA

                        
6 / 2

                    

                    
                    

                        
可旋转键数

                        
13

                    

                    
                    
                    

                        
重原子数

                        
34

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A broad-spectrum antiseptic agent that disrupts microbial cell membranes, effective against bacteria, fungi, and some viruses, used extensively for skin and wound disinfection, hand sanitization, and oral hygiene. It binds to skin and mucous membranes for prolonged residual antimicrobial activity. It is a cornerstone of infection control protocols in healthcare settings.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Chlorhexidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL790.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9552079.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.