Dabigatran
An anticoagulant that directly inhibits thrombin, a key protein in the blood clotting process. It is used to prevent blood clots and strokes in certain patients.
分子量
471.5100 g/mol
LogP
1.70
TPSA
150.00 Ų
Lipinski 五规则
符合
治疗领域
药物分类
作用机制
Direct thrombin (Factor IIa) inhibitor.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Direct thrombin (Factor IIa) inhibitor.
二维结构
Cite this structure
Embed this structure
SMILES
CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
InChI
InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
Molecular Formula
C25H25N7O3
HBD / HBA
4 / 7
可旋转键数
9
重原子数
35
Ibuprofen with dabigatran increases GI bleeding risk through additive effects; dabigatran itself carries a higher inherent GI bleeding risk than other DOACs.
Diltiazem increases dabigatran plasma levels through P-glycoprotein inhibition, potentially raising bleeding risk without a change in INR (dabigatran has no INR to monitor).
Cyclosporine dramatically increases dabigatran exposure through P-gp inhibition, raising the risk of serious or life-threatening bleeding.
Low-dose aspirin combined with dabigatran increases bleeding risk; clinical evidence suggests a 2-fold increase in major bleeding events.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
An anticoagulant that directly inhibits thrombin, a key protein in the blood clotting process. It is used to prevent blood clots and strokes in certain patients.
Direct thrombin (Factor IIa) inhibitor.
Key pharmacokinetic parameters for Dabigatran: Half-life: 12-17 hours.
Yes, Dabigatran is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- PubChem — National Center for Biotechnology Information (NCBI). CID 216210. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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