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Dabigatran

Phase 4 已批准 Small molecule
Half-Life
12-17 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
471.5 g/mol
LogP
1.7
Phase
4

Dabigatran is an oral anticoagulant that directly inhibits thrombin, the enzyme that converts fibrinogen to fibrin at the final step of the clotting cascade. It prevents strokes in atrial fibrillation and treats and prevents venous blood clots. Marketed as Pradaxa, it has the formula C25H25N7O3 and, unlike warfarin, requires no routine coagulation monitoring.

An anticoagulant that directly inhibits thrombin, a key protein in the blood clotting process. It is used to prevent blood clots and strokes in certain patients.

分子量

471.5100 g/mol

LogP

1.70

TPSA

150.00 Ų

Lipinski 五规则

符合

药物分类

B — B - Blood and Blood Forming Organs

作用机制

Direct thrombin (Factor IIa) inhibitor.

Pharmacokinetics (PK)

Half-Life 12-17 hours

Pharmacodynamics (PD)

机制

Direct thrombin (Factor IIa) inhibitor.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N

                

                

                
                

                    
InChI

                    
InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H25N7O3

                    

                    
                    

                        
HBD / HBA

                        
4 / 7

                    

                    
                    

                        
可旋转键数

                        
9

                    

                    
                    
                    

                        
重原子数

                        
35

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            F2 (Thrombin)
                            Inhibitor
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            ABCB1 (P-glycoprotein)
                            Substrate
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Dabigatran + Ibuprofen
                            
                        

                        
                        
Ibuprofen with dabigatran increases GI bleeding risk through additive effects; dabigatran itself carries a higher inherent GI bleeding risk than other DOACs.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Dabigatran + Diltiazem
                            
                        

                        
                        
Diltiazem increases dabigatran plasma levels through P-glycoprotein inhibition, potentially raising bleeding risk without a change in INR (dabigatran has no INR to monitor).

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Dabigatran + Cyclosporine
                            
                        

                        
                        
Cyclosporine dramatically increases dabigatran exposure through P-gp inhibition, raising the risk of serious or life-threatening bleeding.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Dabigatran + Aspirin
                            
                        

                        
                        
Low-dose aspirin combined with dabigatran increases bleeding risk; clinical evidence suggests a 2-fold increase in major bleeding events.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
An anticoagulant that directly inhibits thrombin, a key protein in the blood clotting process. It is used to prevent blood clots and strokes in certain patients.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Direct thrombin (Factor IIa) inhibitor.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Dabigatran: Half-life: 12-17 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Dabigatran is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Warfarin
                            Small molecule
                        
                        
                        
                            Clopidogrel
                            Small molecule
                        
                        
                        
                            Apixaban
                            Small molecule
                        
                        
                        
                            Rivaroxaban
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 216210.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.