Dipivefrin
A prodrug of epinephrine (adrenaline) used as eye drops to lower intraocular pressure in open-angle glaucoma. After penetrating the eye, it is converted to epinephrine, which reduces fluid production and increases drainage within the eye. The prodrug form penetrates the cornea more effectively than epinephrine itself.
分子量
351.4000 g/mol
LogP
2.90
TPSA
84.90 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
二维结构
Cite this structure
Embed this structure
SMILES
CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1
InChI
InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3
Molecular Formula
C19H29NO5
HBD / HBA
2 / 6
可旋转键数
9
重原子数
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A prodrug of epinephrine (adrenaline) used as eye drops to lower intraocular pressure in open-angle glaucoma. After penetrating the eye, it is converted to epinephrine, which reduces fluid production and increases drainage within the eye. The prodrug form penetrates the cornea more effectively than epinephrine itself.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Dipivefrin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201262. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3105. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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