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Duloxetine Hydrochloride

CHEMBL1200328 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
333.9 g/mol
LogP
—
Phase
4

A hydrochloride salt form of duloxetine used to treat major depressive disorder, generalized anxiety disorder, and chronic pain conditions. Like the base form, it boosts serotonin and norepinephrine levels in the brain.

分子量

333.9000 g/mol

TPSA

49.50 Ų

治疗领域

Cardiovascular Disease Respiratory Disease Pain Management Ophthalmology Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Oncology Gastroesophageal Reflux Disease Inflammatory Bowel Disease Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Type 2 Diabetes Major Depressive Disorder Breast Cancer Chronic Pain Prostate Cancer Colorectal Cancer

作用机制

Serotonin-norepinephrine reuptake inhibitor (SNRI).

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Serotonin-norepinephrine reuptake inhibitor (SNRI).

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CNCC[C@H](Oc1cccc2ccccc12)c1cccs1.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H20ClNOS

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
可旋转键数

                        
6

                    

                    
                    
                    

                        
重原子数

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A hydrochloride salt form of duloxetine used to treat major depressive disorder, generalized anxiety disorder, and chronic pain conditions. Like the base form, it boosts serotonin and norepinephrine levels in the brain.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Serotonin-norepinephrine reuptake inhibitor (SNRI).

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Duloxetine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200328.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60834.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.