Forodesine Hydrochloride
A hydrochloride salt form of forodesine, a purine nucleoside phosphorylase inhibitor investigated for treating T-cell malignancies including leukemia and lymphoma. The hydrochloride salt improves the compound's solubility and bioavailability for clinical use. It acts selectively on lymphoid cells, potentially sparing other tissues.
分子量
302.7100 g/mol
TPSA
130.00 Ų
治疗领域
作用机制
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
二维结构
Cite this structure
Embed this structure
SMILES
Cl.O=c1[nH]cnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12
InChI
InChI=1S/C11H14N4O4.ClH/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19;/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19);1H/t5-,7+,9-,10+;/m1./s1
Molecular Formula
C11H15ClN4O4
HBD / HBA
7 / 6
可旋转键数
2
重原子数
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A hydrochloride salt form of forodesine, a purine nucleoside phosphorylase inhibitor investigated for treating T-cell malignancies including leukemia and lymphoma. The hydrochloride salt improves the compound's solubility and bioavailability for clinical use. It acts selectively on lymphoid cells, potentially sparing other tissues.
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Yes, Forodesine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL550755. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135449327. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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