Forodesine Hydrochloride
A hydrochloride salt form of forodesine, a purine nucleoside phosphorylase inhibitor investigated for treating T-cell malignancies including leukemia and lymphoma. The hydrochloride salt improves the compound's solubility and bioavailability for clinical use. It acts selectively on lymphoid cells, potentially sparing other tissues.
Molecular Weight
302.7100 g/mol
TPSA
130.00 Ų
Therapeutic Areas
Mechanism of Action
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
2D Structure
Cite this structure
Embed this structure
SMILES
Cl.O=c1[nH]cnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12
InChI
InChI=1S/C11H14N4O4.ClH/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19;/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19);1H/t5-,7+,9-,10+;/m1./s1
Molecular Formula
C11H15ClN4O4
HBD / HBA
7 / 6
Rotatable Bonds
2
Heavy Atoms
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A hydrochloride salt form of forodesine, a purine nucleoside phosphorylase inhibitor investigated for treating T-cell malignancies including leukemia and lymphoma. The hydrochloride salt improves the compound's solubility and bioavailability for clinical use. It acts selectively on lymphoid cells, potentially sparing other tissues.
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Yes, Forodesine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL550755. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135449327. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="forodesine-hydrochloride"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/forodesine-hydrochloride/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/forodesine-hydrochloride/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/forodesine-hydrochloride/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="forodesine-hydrochloride"></drugfyi-drug>