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Fruquintinib

CHEMBL4303214 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
393.4 g/mol
LogP
3.4
Phase
4

This oral medication inhibits VEGF receptors that promote tumor blood vessel formation, cutting off the blood supply that colorectal and lung tumors need to grow. It is used in later lines of treatment for metastatic colorectal cancer and non-small cell lung cancer that has progressed on prior therapies.

分子量

393.4000 g/mol

LogP

3.40

TPSA

95.70 Ų

Lipinski 五规则

符合

治疗领域

Melanoma Ovarian Cancer Pancreatic Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Colorectal Cancer

作用机制

Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CNC(=O)c1c(C)oc2cc(Oc3ncnc4cc(OC)c(OC)cc34)ccc12

                

                

                
                

                    
InChI

                    
InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H19N3O5

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This oral medication inhibits VEGF receptors that promote tumor blood vessel formation, cutting off the blood supply that colorectal and lung tumors need to grow. It is used in later lines of treatment for metastatic colorectal cancer and non-small cell lung cancer that has progressed on prior therapies.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Fruquintinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4303214.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 44480399.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.