Fruquintinib
This oral medication inhibits VEGF receptors that promote tumor blood vessel formation, cutting off the blood supply that colorectal and lung tumors need to grow. It is used in later lines of treatment for metastatic colorectal cancer and non-small cell lung cancer that has progressed on prior therapies.
Molecular Weight
393.4000 g/mol
LogP
3.40
TPSA
95.70 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
2D Structure
Cite this structure
Embed this structure
SMILES
CNC(=O)c1c(C)oc2cc(Oc3ncnc4cc(OC)c(OC)cc34)ccc12
InChI
InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
Molecular Formula
C21H19N3O5
HBD / HBA
1 / 7
Rotatable Bonds
5
Heavy Atoms
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This oral medication inhibits VEGF receptors that promote tumor blood vessel formation, cutting off the blood supply that colorectal and lung tumors need to grow. It is used in later lines of treatment for metastatic colorectal cancer and non-small cell lung cancer that has progressed on prior therapies.
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Yes, Fruquintinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4303214. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44480399. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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