Hydroflumethiazide
A thiazide diuretic used to treat high blood pressure and edema by increasing urinary sodium and water excretion from the kidneys, reducing blood volume and relaxing blood vessel walls. It may be used alone or in combination with other antihypertensive agents for better blood pressure control. Monitoring of electrolytes, particularly potassium, is recommended during treatment.
分子量
331.3000 g/mol
LogP
0.40
TPSA
135.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
二维结构
Cite this structure
Embed this structure
SMILES
NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O
InChI
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
Molecular Formula
C8H8F3N3O4S2
HBD / HBA
3 / 10
可旋转键数
1
重原子数
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A thiazide diuretic used to treat high blood pressure and edema by increasing urinary sodium and water excretion from the kidneys, reducing blood volume and relaxing blood vessel walls. It may be used alone or in combination with other antihypertensive agents for better blood pressure control. Monitoring of electrolytes, particularly potassium, is recommended during treatment.
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Yes, Hydroflumethiazide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1763. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3647. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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