Indapamide
This thiazide-like diuretic is used to treat high blood pressure and fluid retention (edema) associated with heart failure. It reduces blood pressure by promoting sodium and water excretion in the kidneys, decreasing blood volume, and also by directly relaxing blood vessels. It is often preferred for hypertension due to its neutral effect on blood lipids and glucose.
分子量
365.8000 g/mol
LogP
2.90
TPSA
101.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
二维结构
Cite this structure
Embed this structure
SMILES
CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1
InChI
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
Molecular Formula
C16H16ClN3O3S
HBD / HBA
2 / 5
可旋转键数
3
重原子数
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This thiazide-like diuretic is used to treat high blood pressure and fluid retention (edema) associated with heart failure. It reduces blood pressure by promoting sodium and water excretion in the kidneys, decreasing blood volume, and also by directly relaxing blood vessels. It is often preferred for hypertension due to its neutral effect on blood lipids and glucose.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Indapamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL406. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3702. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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