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Isoflurophate

CHEMBL1025 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
184.2 g/mol
LogP
1.2
Phase
4

This irreversible cholinesterase inhibitor works by permanently blocking the enzyme that breaks down acetylcholine, causing prolonged nerve stimulation; it was used historically as long-acting eye drops to treat glaucoma and certain forms of crossed eyes. Due to its toxicity and the availability of safer alternatives, its medical use has become very limited.

分子量

184.1500 g/mol

LogP

1.20

TPSA

35.50 Ų

Lipinski 五规则

符合

治疗领域

Parkinson's Disease

作用机制

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)OP(=O)(F)OC(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H14FO3P

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
可旋转键数

                        
4

                    

                    
                    
                    

                        
重原子数

                        
11

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This irreversible cholinesterase inhibitor works by permanently blocking the enzyme that breaks down acetylcholine, causing prolonged nerve stimulation; it was used historically as long-acting eye drops to treat glaucoma and certain forms of crossed eyes. Due to its toxicity and the availability of safer alternatives, its medical use has become very limited.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Isoflurophate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1025.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5936.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.