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Lamotrigine

CHEMBL741 Phase 4 已批准 Small molecule
Half-Life
25 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
256.1 g/mol
LogP
1.4
Phase
4

An anticonvulsant and mood stabilizer used to treat epilepsy and bipolar disorder, and studied for potential benefits in Alzheimer's disease. It works by blocking voltage-gated sodium channels and reducing the release of excitatory neurotransmitters.

分子量

256.0910 g/mol

LogP

1.40

TPSA

90.70 Ų

Lipinski 五规则

符合

治疗领域

Pain Management Asthma Parkinson's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Multiple Sclerosis Stroke Obesity Major Depressive Disorder Chronic Pain

药物分类

N — N - Nervous System

作用机制

Sodium channel blocker inhibiting glutamate release.

Pharmacokinetics (PK)

Half-Life 25 hours

Pharmacodynamics (PD)

机制

Sodium channel blocker inhibiting glutamate release.

二维结构

SVG PNG

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SMILES

                    
Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H7Cl2N5

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
可旋转键数

                        
1

                    

                    
                    
                    

                        
重原子数

                        
16

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            SCN9A (Sodium Channel Nav1.7)
                            Blocker
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Lamotrigine + Valproic Acid
                            
                        

                        
                        
Valproic acid doubles lamotrigine plasma concentrations by inhibiting its glucuronidation; the combination is associated with Stevens-Johnson syndrome and toxic epidermal necrolysis.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Lamotrigine + Sertraline
                            
                        

                        
                        
Sertraline may increase lamotrigine plasma concentrations by inhibiting its glucuronidation, potentially causing lamotrigine toxicity.

                        
                    
                    
                    
                        

                            

  
  Minor


                            
                                Lamotrigine + Acetaminophen
                            
                        

                        
                        
Repeated acetaminophen use may modestly lower lamotrigine plasma levels through induction of UGT glucuronidation pathways, though the clinical impact is generally small.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Lamotrigine + Carbamazepine
                            
                        

                        
                        
Carbamazepine reduces lamotrigine plasma concentrations by approximately 50% through enzyme induction, requiring lamotrigine dose adjustment.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
An anticonvulsant and mood stabilizer used to treat epilepsy and bipolar disorder, and studied for potential benefits in Alzheimer's disease. It works by blocking voltage-gated sodium channels and reducing the release of excitatory neurotransmitters.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Sodium channel blocker inhibiting glutamate release.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Lamotrigine: Half-life: 25 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Lamotrigine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Acetaminophen
                            Small molecule
                        
                        
                        
                            Aspirin
                            Small molecule
                        
                        
                        
                            Sertraline
                            Small molecule
                        
                        
                        
                            Escitalopram
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL741.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3878.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.