Larotrectinib

CHEMBL3889654 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

428.4 g/mol

LogP

1.7

Phase

4

A highly selective TRK inhibitor used to treat solid tumors with NTRK gene fusions, regardless of where in the body the cancer originated. It targets a specific genetic mutation driving tumor growth across multiple cancer types.

分子量

428.4000 g/mol

LogP

1.70

TPSA

86.00 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Melanoma Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1

InChI

InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

Molecular Formula

C21H22F2N6O2

HBD / HBA

2 / 7

可旋转键数

3

重原子数

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A highly selective TRK inhibitor used to treat solid tumors with NTRK gene fusions, regardless of where in the body the cancer originated. It targets a specific genetic mutation driving tumor growth across multiple cancer types.

Yes, Larotrectinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3889654. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 46188928. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C21H22F2N6O2
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.