Leflunomide

CHEMBL960 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

270.2 g/mol

LogP

2.5

Phase

4

A disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid and psoriatic arthritis by suppressing the overactive immune response that causes joint damage. It inhibits an enzyme involved in the production of immune cells.

分子量

270.2100 g/mol

LogP

2.50

TPSA

55.10 Å²

Lipinski 五规则

符合

治疗领域

Melanoma Pancreatic Cancer Age-Related Macular Degeneration Respiratory Disease Non-Small Cell Lung Cancer Rheumatoid Arthritis Migraine Generalized Anxiety Disorder Psoriasis Systemic Lupus Erythematosus Transplant Medicine Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure

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SMILES

Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1

InChI

InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

Molecular Formula

C12H9F3N2O2

HBD / HBA

1 / 6

可旋转键数

2

重原子数

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid and psoriatic arthritis by suppressing the overactive immune response that causes joint damage. It inhibits an enzyme involved in the production of immune cells.

Yes, Leflunomide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL960. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3899. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C12H9F3N2O2
同义词: 2

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.