Leflunomide

CHEMBL960 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

270.2 g/mol

LogP

2.5

Phase

4

A disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid and psoriatic arthritis by suppressing the overactive immune response that causes joint damage. It inhibits an enzyme involved in the production of immune cells.

Molecular Weight

270.2100 g/mol

LogP

2.50

TPSA

55.10 Å²

Lipinski RO5

Pass

Therapeutic Areas

Age-Related Macular Degeneration Breast Cancer Colorectal Cancer Generalized Anxiety Disorder Melanoma Migraine Non-Small Cell Lung Cancer Pancreatic Cancer Prostate Cancer Psoriasis Respiratory Disease Rheumatoid Arthritis Systemic Lupus Erythematosus Transplant Medicine

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure

Embed this structure

SMILES

Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1

InChI

InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

Molecular Formula

C12H9F3N2O2

HBD / HBA

1 / 6

Rotatable Bonds

2

Heavy Atoms

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid and psoriatic arthritis by suppressing the overactive immune response that causes joint damage. It inhibits an enzyme involved in the production of immune cells.

Yes, Leflunomide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL960. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3899. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

Looking for patient-friendly information?

Leflunomide on PillFYI

Structure

Quick Data

Formula: C12H9F3N2O2
Synonyms: 2

External Links

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.