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Memantine Hydrochloride

CHEMBL1699 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
215.8 g/mol
LogP
—
Phase
4

A hydrochloride salt form of memantine, an NMDA antagonist used to treat moderate-to-severe Alzheimer's disease symptoms by regulating glutamate signaling in the brain.

分子量

215.7600 g/mol

TPSA

26.00 Ų

治疗领域

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Pain Management Non-Small Cell Lung Cancer Osteoporosis Alzheimer's Disease Parkinson's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Systemic Lupus Erythematosus Multiple Sclerosis Oncology Stroke Major Depressive Disorder Breast Cancer Chronic Pain Prostate Cancer Colorectal Cancer

作用机制

Non-competitive NMDA receptor antagonist.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Non-competitive NMDA receptor antagonist.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC12CC3CC(C)(C1)CC(N)(C3)C2.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H22ClN

                    

                    
                    

                        
HBD / HBA

                        
2 / 1

                    

                    
                    

                        
可旋转键数

                        
0

                    

                    
                    
                    

                        
重原子数

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A hydrochloride salt form of memantine, an NMDA antagonist used to treat moderate-to-severe Alzheimer's disease symptoms by regulating glutamate signaling in the brain.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Non-competitive NMDA receptor antagonist.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Memantine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1699.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 181458.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.