Montelukast
This medication blocks leukotriene receptors, reducing airway inflammation and constriction in the lungs and relieving allergy symptoms in the nose and skin. It is taken once daily by mouth to prevent asthma attacks and treat allergic rhinitis and hives.
分子量
586.1800 g/mol
LogP
7.70
TPSA
95.70 Ų
Lipinski 五规则
不符合
治疗领域
药物分类
作用机制
Selective leukotriene D4 receptor antagonist.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective leukotriene D4 receptor antagonist.
二维结构
Cite this structure
Embed this structure
SMILES
CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1
InChI
InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
Molecular Formula
C35H36ClNO3S
HBD / HBA
2 / 5
可旋转键数
12
重原子数
41
Phenytoin, a potent CYP inducer, can increase the metabolism of montelukast, potentially reducing its plasma levels and therapeutic efficacy.
Fluconazole inhibits CYP2C8-mediated metabolism of montelukast, modestly increasing montelukast plasma concentrations; the clinical impact is generally minor given montelukast's wide therapeutic index.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This medication blocks leukotriene receptors, reducing airway inflammation and constriction in the lungs and relieving allergy symptoms in the nose and skin. It is taken once daily by mouth to prevent asthma attacks and treat allergic rhinitis and hives.
Selective leukotriene D4 receptor antagonist.
Key pharmacokinetic parameters for Montelukast: Half-life: 2.7-5.5 hours.
Yes, Montelukast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL787. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5281040. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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