Naloxegol
This medication is used to treat opioid-induced constipation in adults taking opioid pain medicines for non-cancer pain. It works by blocking opioid receptors specifically in the gut without affecting pain relief in the rest of the body, allowing normal bowel function to resume.
分子量
651.8000 g/mol
LogP
-1.00
TPSA
127.00 Ų
Lipinski 五规则
不符合
治疗领域
作用机制
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
二维结构
Cite this structure
Embed this structure
SMILES
C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](OCCOCCOCCOCCOCCOCCOCCOC)CC[C@@]3(O)[C@H]1C5
InChI
InChI=1S/C34H53NO11/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2/h3-5,28-29,32,36-37H,1,6-25H2,2H3/t28-,29+,32-,33-,34+/m0/s1
Molecular Formula
C34H53NO11
HBD / HBA
2 / 12
可旋转键数
24
重原子数
46
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This medication is used to treat opioid-induced constipation in adults taking opioid pain medicines for non-cancer pain. It works by blocking opioid receptors specifically in the gut without affecting pain relief in the rest of the body, allowing normal bowel function to resume.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Naloxegol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2219418. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 56959087. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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