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Netupitant

CHEMBL206253 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
578.6 g/mol
LogP
6.8
Phase
4

This medication is used in combination with another drug to prevent nausea and vomiting caused by cancer chemotherapy. It works by blocking substance P receptors in the brain that trigger the vomiting reflex, and is taken as a single oral dose before chemotherapy.

分子量

578.6000 g/mol

LogP

6.80

TPSA

39.70 Ų

Lipinski 五规则

不符合

治疗领域

Oncology Breast Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

                    
Cc1ccccc1-c1cc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C30H32F6N4O

                    

                    
                    

                        
HBD / HBA

                        
- / 10

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
41

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This medication is used in combination with another drug to prevent nausea and vomiting caused by cancer chemotherapy. It works by blocking substance P receptors in the brain that trigger the vomiting reflex, and is taken as a single oral dose before chemotherapy.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Netupitant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL206253.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6451149.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.