Phthalylsulfathiazole

CHEMBL1524273 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

403.4 g/mol

LogP

1.1

Phase

4

Phthalylsulfathiazole is a poorly absorbed sulfonamide antibiotic that releases sulfathiazole in the intestinal lumen after hydrolysis by intestinal bacteria, exerting local antibacterial activity by inhibiting bacterial dihydropteroate synthase and folate synthesis. It was used for pre-operative bowel sterilization and treatment of intestinal infections, though it has been largely superseded by newer antibiotics.

分子量

403.4000 g/mol

LogP

1.10

TPSA

162.00 Å²

Lipinski 五规则

符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

O=C(O)c1ccccc1C(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1

InChI

InChI=1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23)

Molecular Formula

C17H13N3O5S2

HBD / HBA

3 / 8

可旋转键数

6

重原子数

27

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Phthalylsulfathiazole is a poorly absorbed sulfonamide antibiotic that releases sulfathiazole in the intestinal lumen after hydrolysis by intestinal bacteria, exerting local antibacterial activity by inhibiting bacterial dihydropteroate synthase and folate synthesis. It was used for pre-operative bowel sterilization and treatment of intestinal infections, though it has been largely superseded by newer antibiotics.

Yes, Phthalylsulfathiazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1524273. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4806. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C17H13N3O5S2

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.