Polymyxin B
Polymyxin B is a cyclic lipopeptide antibiotic of the polymyxin class that disrupts the integrity of the bacterial outer membrane of Gram-negative bacteria by binding to lipopolysaccharide and displacing calcium and magnesium ions, increasing membrane permeability and causing bactericidal cell death. It is used for the treatment of serious infections caused by multidrug-resistant Gram-negative organisms, particularly Pseudomonas aeruginosa and Acinetobacter baumannii, often as a last-resort antibiotic.
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Polymyxin B is a cyclic lipopeptide antibiotic of the polymyxin class that disrupts the integrity of the bacterial outer membrane of Gram-negative bacteria by binding to lipopolysaccharide and displacing calcium and magnesium ions, increasing membrane permeability and causing bactericidal cell death. It is used for the treatment of serious infections caused by multidrug-resistant Gram-negative organisms, particularly Pseudomonas aeruginosa and Acinetobacter baumannii, often as a last-resort antibiotic.
Yes, Polymyxin B is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5314354. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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